Tatsuhito Himeno Selected Research

Diabetic Neuropathies (Diabetic Neuropathy)

8/2021	Alterations of retinal thickness measured by optical coherence tomography correlate with neurophysiological measures in diabetic polyneuropathy.
7/2021	Neuroretinal dysfunction revealed by a flicker electroretinogram correlated with peripheral nerve dysfunction and parameters of atherosclerosis in patients with diabetes.
4/2021	Point-of-care nerve conduction device predicts the severity of diabetic polyneuropathy: A quantitative, but easy-to-use, prediction model.
1/2021	Glucagon Prevents Cytotoxicity Induced by Methylglyoxal in a Rat Neuronal Cell Line Model.
1/2021	Sustainable Effects of Human Dental Pulp Stem Cell Transplantation on Diabetic Polyneuropathy in Streptozotocine-Induced Type 1 Diabetes Model Mice.
10/2020	Secreted Factors from Stem Cells of Human Exfoliated Deciduous Teeth Directly Activate Endothelial Cells to Promote All Processes of Angiogenesis.
10/2020	Deficiency of glucagon gene-derived peptides induces peripheral polyneuropathy in mice.
1/2020	Secreted factors from cultured dental pulp stem cells promoted neurite outgrowth of dorsal root ganglion neurons and ameliorated neural functions in streptozotocin-induced diabetic mice.
1/2020	Transplantation of human dental pulp stem cells ameliorates diabetic polyneuropathy in streptozotocin-induced diabetic nude mice: the role of angiogenic and neurotrophic factors.
1/2020	Diabetic polyneuropathy: Progress in diagnostic strategy and novel target discovery, but stagnation in drug development.

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Tatsuhito Himeno Research Topics

Disease

22	Diabetic Neuropathies (Diabetic Neuropathy) 08/2021 - 01/2011
4	Diabetes Complications 01/2021 - 01/2018
3	Polyneuropathies (Polyneuropathy) 10/2020 - 09/2011
2	Hypoglycemia (Reactive Hypoglycemia) 10/2019 - 01/2017
2	Type 2 Diabetes Mellitus (MODY) 10/2017 - 01/2017
1	Peripheral Nervous System Diseases (PNS Diseases) 01/2022
1	Diabetic Retinopathy (Retinopathy, Diabetic) 08/2021
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2021
1	Vascular Diseases (Vascular Disease) 10/2020
1	Body Weight (Weight, Body) 10/2017
1	Wounds and Injuries (Trauma) 09/2014
1	Bone Resorption 02/2014
1	Encephalitis (Encephalitis, Rasmussen) 02/2014
1	Nerve Degeneration 01/2013
1	Neuralgia (Stump Neuralgia) 01/2011
1	Hyperalgesia 01/2011
1	Cushing Syndrome 01/2011
1	Acth-Independent Macronodular Adrenal Hyperplasia 01/2011

Drug/Important Bio-Agent (IBA)

11	NAD (NADH)IBA 01/2022 - 09/2011
7	Streptozocin (Streptozotocin)FDA Link 01/2021 - 01/2011
4	Glucose (Dextrose)FDA LinkGeneric 10/2019 - 01/2011
2	Therapeutic UsesIBA 01/2021 - 01/2020
2	Nerve Growth Factor (NGF)IBA 01/2021 - 01/2020
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2021 - 01/2020
2	Peptides (Polypeptides)IBA 10/2020 - 01/2011
2	Neuroprotective AgentsIBA 05/2019 - 02/2014
2	Hypoglycemic Agents (Hypoglycemics)IBA 10/2017 - 01/2017
1	Retinaldehyde (Retinal)IBA 08/2021
1	Glucagon (Glukagon)FDA Link 10/2020
1	Nerve Growth Factors (Neurotrophins)IBA 01/2020
1	Neutralizing AntibodiesIBA 01/2020
1	Pharmaceutical PreparationsIBA 01/2020
1	Conditioned Culture MediaIBA 01/2020
1	Aldehyde Reductase (Aldose Reductase)IBA 01/2019
1	epalrestatIBA 01/2019
1	polyolIBA 01/2019
1	ranirestatIBA 01/2019
1	2- (2,5- difluorophenyl)- 5- (2- (methylsulfonyl)- 2,6- dihydropyrrolo(3,4- c)pyrazol- 5(4H)- yl)tetrahydro- 2H- pyran- 3- amineIBA 10/2017
1	Dipeptidyl-Peptidase IV InhibitorsIBA 10/2017
1	trelagliptinIBA 10/2017
1	Glycated Serum AlbuminIBA 10/2017
1	ipragliflozinIBA 01/2017
1	dapagliflozinIBA 01/2017
1	1,5- anhydro- 1- (5- (4- ethoxybenzyl)- 2- methoxy- 4- methylphenyl)- 1- thioglucitolIBA 01/2017
1	6- ((4- ethylphenyl)methyl)- 3',4',5',6'- tetrahydro- 6'- (hydroxymethyl)spiro(isobenzofuran- 1(3H),2'- (2H)pyran)- 3',4',5'- triolIBA 01/2017
1	CanagliflozinIBA 01/2017
1	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2017
1	SodiumIBA 01/2017
1	SymportersIBA 01/2017
1	CytokinesIBA 03/2015
1	Calcium-Binding ProteinsIBA 02/2014
1	Advanced Glycation End ProductsIBA 02/2014
1	Glucagon-Like Peptide-1 ReceptorIBA 09/2011
1	Exenatide (Byetta)FDA Link 09/2011
1	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2011
1	gastric inhibitory polypeptide receptorIBA 01/2011
1	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2011
1	AcetoneIBA 01/2011
1	Oxidoreductases (Dehydrogenase)IBA 01/2011

Therapy/Procedure

8	Transplantation 01/2021 - 01/2011
3	Stem Cell Transplantation 01/2021 - 12/2017
2	Cell Transplantation 12/2017 - 03/2015
1	Surgical Amputation (Amputations) 01/2018
1	Therapeutics 03/2015
1	Autologous Transplantation 01/2011